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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Piperlongumine, Paclitaxel
Phytochemical Name Piperlongumine (PubChem CID: 637858 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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Structure of
Anticancer Drug		 2D-img
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 10
Ref_1
Pair Name Piperlongumine, Paclitaxel
Disease Info [ICD-11: 2B90.Z] Colon cancer Investigative
Biological Phenomena Induction-->ROS mediated cell death
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression BIRC5 hsa332
Up-regulation Expression TP53 hsa7157
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression SMAD4 hsa4089
Down-regulation Expression FN1 hsa2335
Down-regulation Expression CDH2 hsa1000
Down-regulation Expression CTNNB1 hsa1499
Down-regulation Expression TWIST1 hsa7291
Up-regulation Expression ROS1 hsa6098
In Vitro Model Intestine 407 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_1907
HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
Result Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
03. Reference
No. Title Href
1 Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells. Biomed Pharmacother. 2020 Aug;128:110243. doi: 10.1016/j.biopha.2020.110243. Click
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