| Pair Name | Piperlongumine, Paclitaxel | ||
| Phytochemical Name | Piperlongumine (PubChem CID: 637858 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Piperlongumine, Paclitaxel | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->ROS mediated cell death | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Down-regulation | Expression | CDH2 | hsa1000 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Down-regulation | Expression | CTNNB1 | hsa1499 | |
| Down-regulation | Expression | FN1 | hsa2335 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | SMAD4 | hsa4089 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | TWIST1 | hsa7291 | |
| In Vitro Model | Intestine 407 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_1907 |
| HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 | |
| Result | Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells. Biomed Pharmacother. 2020 Aug;128:110243. doi: 10.1016/j.biopha.2020.110243. | Click |
